PopVax

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Principal Scientist - Immunology

  • Research & Development (Wet Lab)
  • Full-time
  • Hyderabad, IN

2022-09-22 08:41:03 UTC

PopVax is an Indian biotechnology company based in Hyderabad building a novel thermostable, low-cost, and safe second-generation mRNA platform for rationally-designed broadly-protective multi-epitope vaccines. We’re starting with a 4-8 °C refrigerator-stable booster vaccine candidate that is intended to protect against the entire sarbecovirus sub-family, including current and future strains of SARS-CoV-2 (the virus which causes COVID-19), and some other beta-coronaviruses such as MERS-CoV, using a structural reverse-vaccinology approach to antigen design.

We are seeking an exceptional experienced senior immunologist with specific expertise in vaccine development to spearhead the overall immunology efforts at PopVax.

RESPONSIBILITES

  • Contribute to antigen design, and help predict the impact of changes to antigen design on immune response

  • Plan and execute in vitro and in vivo experiments to comprehensively characterize the immunogenecity of mRNA-LNP vaccine candidates

  • Lead communication and drive collaboration between the immunology and the antigen design, mRNA, and formulation teams

  • Coordinate the overall execution of studies with external partners and contract research organisations

  • Develop study outlines, detailed timelines and oversee the logistics for execution of parallel and staggered experiments

  • Ensure effective and thorough documentation, analysis, and interpretation of the experimental data generated by the immunology team

QUALIFICATIONS 

  • PhD and 8+ years or Masters and 10+ years of experience in immunology, biochemistry, life sciences, or a related discipline, with a minimum of 5 years of experience in vaccine design and development in academia or industry

  • Experience in performing and in depth understanding of routine immunology techniques such as ELISA, ELISPOT, multiplex assays, and multi-colour flow cytometry including intracellular cytokine staining

  • Expertise (and ideally publications) in viral immunology — experience in structural reverse vaccinology in particular is a huge plus

  • In-depth understanding of the design, execution, analysis of virus and pseudovirus neutralization assays

  • Familiarity with data analysis software such as FlowJo and Prism

  • Strong written and oral communication skills

  • A proven track record of research publications and, ideally, presentations at research conferences

  • Proven leadership and mentorship experience in pre-clinical research and development

  • Prior work on or experience with myocarditis is a plus

We offer very competitive compensation, comprehensive health insurance covering immediate family (including pre-existing conditions), and, most importantly, a collaborative work environment focused on solving the cutting-edge multidisciplinary challenges of our novel mRNA platform.